Use of this medicine may cause lack of interest, low mood, sleep disturbances in some patients. It should be administered with caution in patients with an active/past instance of depression.This medicine is not recommended for use in children below 5 years of age. This medicine should be used with caution in patients suffering from Parkinson’s disease. It should be used only when the potential benefits outweigh the risks involved with use. This medicine is not recommended for use if you have a genetic disorder of the blood and skin (Porphyria). The risk of adverse effects are significantly high and hence your doctor may suggest a suitable alternative.